Arrive at Tocumen International Airport in Panama City and check into your hotel. In the evening, visit Casco Viejo, the historic district, for a walking tour and dinner. Explore the colonial architecture, plazas, and vibrant nightlife.
In the morning, visit the Miraflores Locks at the Panama Canal. Explore the visitor center and watch ships pass through the locks. In the afternoon, take a tour of the Panama Canal Museum to learn about the history and significance of the canal. For the evening, enjoy dinner at a restaurant overlooking the canal or head back to Casco Viejo for more dining options.
Spend the full day on a day trip to the San Blas Islands, a beautiful archipelago in the Caribbean. Enjoy snorkeling, swimming, and relaxing on pristine beaches. Meet the Guna Yala people and learn about their culture. Return to Panama City and your hotel for the night.
In the morning, visit the Biomuseo, a museum dedicated to Panama's biodiversity designed by architect Frank Gehry. In the afternoon, explore the Amador Causeway, which offers great views of the city skyline and the canal. Rent a bike or go for a leisurely walk. In the evening, visit a local market or enjoy some shopping in the city. Try traditional Panamanian cuisine for dinner.
Travel to Anton Valley, a picturesque town located in the crater of an extinct volcano, for a full day trip. Visit El Nispero Zoo and Botanical Garden, the Chorro El Macho waterfall, and the local hot springs. Return to Panama City and your hotel for the night.
Depending on your flight time, you might have a chance to visit the Metropolitan National Park for a morning hike and wildlife spotting. Check out of your hotel and transfer to Tocumen International Airport for your departure flight.